diff --git a/README.md b/README.md
index ae18633..7d43ae9 100644
--- a/README.md
+++ b/README.md
@@ -15,6 +15,7 @@ make test
 
 ## 📚 Documentation
 - **[Features Guide](docs/FEATURES.md)** - Complete feature documentation
+- **[Keyboard Shortcuts](docs/KEYBOARD_SHORTCUTS.md)** - Keyboard shortcuts for efficient navigation
 - **[Export System](docs/EXPORT_SYSTEM.md)** - Data export functionality and formats
 - **[Development Guide](docs/DEVELOPMENT.md)** - Testing, development, and architecture
 - **[Changelog](docs/CHANGELOG.md)** - Version history and feature evolution
@@ -483,6 +484,30 @@ thechart_data.csv   # User data (created on first run)
 - **`pyproject.toml`**: Project configuration and dependencies
 - **`uv.lock`**: Dependency lock file
 
+### Keyboard Shortcuts
+```bash
+# File Operations
+Ctrl+S          # Save/Add new entry
+Ctrl+Q          # Quit application
+Ctrl+E          # Export data
+
+# Data Management
+Ctrl+N          # Clear entries
+Ctrl+R / F5     # Refresh data
+
+# Window Management
+Ctrl+M          # Manage medicines
+Ctrl+P          # Manage pathologies
+
+# Table Operations
+Delete          # Delete selected entry
+Escape          # Clear selection
+Double-click    # Edit entry
+
+# Help
+F1              # Show keyboard shortcuts help
+```
+
 ---
 
 ## Why uv?
diff --git a/docs/CHANGELOG.md b/docs/CHANGELOG.md
index 5952a29..a7b295e 100644
--- a/docs/CHANGELOG.md
+++ b/docs/CHANGELOG.md
@@ -5,6 +5,40 @@ All notable changes to TheChart project are documented in this file.
 The format is based on [Keep a Changelog](https://keepachangelog.com/en/1.0.0/),
 and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0.html).
 
+## [1.7.0] - 2025-08-05
+
+### ⌨️ Keyboard Shortcuts System
+- **Added**: Comprehensive keyboard shortcuts for improved productivity
+- **Added**: File operations shortcuts (Ctrl+S, Ctrl+Q, Ctrl+E)
+- **Added**: Data management shortcuts (Ctrl+N, Ctrl+R, F5)
+- **Added**: Window management shortcuts (Ctrl+M, Ctrl+P)
+- **Added**: Table operation shortcuts (Delete, Escape)
+- **Added**: Help system shortcut (F1)
+- **Added**: Menu integration showing shortcuts next to menu items
+- **Added**: Button labels updated to show primary shortcuts
+- **Added**: In-app help dialog accessible via F1
+- **Added**: Status bar feedback for all keyboard operations
+- **Improved**: Button text shows shortcuts (e.g., "Add Entry (Ctrl+S)")
+- **Improved**: Case-insensitive shortcuts (Ctrl+S and Ctrl+Shift+S both work)
+
+#### Keyboard Shortcuts Added:
+- **Ctrl+S**: Save/Add new entry
+- **Ctrl+Q**: Quit application (with confirmation)
+- **Ctrl+E**: Export data
+- **Ctrl+N**: Clear entries
+- **Ctrl+R / F5**: Refresh data
+- **Ctrl+M**: Manage medicines
+- **Ctrl+P**: Manage pathologies
+- **Delete**: Delete selected entry (with confirmation)
+- **Escape**: Clear selection
+- **F1**: Show keyboard shortcuts help
+
+### 📚 Documentation Updates
+- **Updated**: FEATURES.md with keyboard shortcuts section
+- **Added**: KEYBOARD_SHORTCUTS.md with comprehensive shortcut reference
+- **Updated**: In-app help system with shortcut information
+- **Updated**: About dialog with keyboard shortcut mention
+
 ## [1.6.1] - 2025-07-31
 
 ### 📚 Documentation Overhaul
diff --git a/docs/FEATURES.md b/docs/FEATURES.md
index 7a3510c..64754aa 100644
--- a/docs/FEATURES.md
+++ b/docs/FEATURES.md
@@ -159,6 +159,37 @@ Professional testing infrastructure with high code coverage.
 - **Real-time Updates**: Immediate feedback and data updates
 - **Error Handling**: Comprehensive error messages and recovery options
 
+### ⌨️ Keyboard Shortcuts
+Comprehensive keyboard shortcuts for efficient navigation and data entry.
+
+#### File Operations:
+- **Ctrl+S**: Save/Add new entry - Quickly save current entry data
+- **Ctrl+Q**: Quit application - Exit with confirmation dialog
+- **Ctrl+E**: Export data - Open export dialog window
+
+#### Data Management:
+- **Ctrl+N**: Clear entries - Clear all input fields for new entry
+- **Ctrl+R / F5**: Refresh data - Reload data from CSV and update displays
+
+#### Window Management:
+- **Ctrl+M**: Manage medicines - Open medicine management window
+- **Ctrl+P**: Manage pathologies - Open pathology management window
+
+#### Table Operations:
+- **Delete**: Delete selected entry - Remove selected table entry with confirmation
+- **Escape**: Clear selection - Clear current table selection
+- **Double-click**: Edit entry - Open edit dialog for selected entry
+
+#### Help System:
+- **F1**: Show keyboard shortcuts - Display help dialog with all shortcuts
+
+#### Integration Features:
+- **Menu Display**: All shortcuts shown in menu bar next to items
+- **Button Labels**: Primary buttons show their keyboard shortcuts
+- **Case Insensitive**: Both Ctrl+S and Ctrl+Shift+S work
+- **Focus Management**: Shortcuts work when main window has focus
+- **Status Feedback**: All operations provide status bar feedback
+
 ## Technical Architecture
 
 ### 🏗️ Modular Design
diff --git a/docs/KEYBOARD_SHORTCUTS.md b/docs/KEYBOARD_SHORTCUTS.md
new file mode 100644
index 0000000..b5f760f
--- /dev/null
+++ b/docs/KEYBOARD_SHORTCUTS.md
@@ -0,0 +1,71 @@
+# Keyboard Shortcuts
+
+TheChart application supports comprehensive keyboard shortcuts for improved productivity and efficient navigation.
+
+## File Operations
+- **Ctrl+S**: Save/Add new entry - Saves the current entry data to the database
+- **Ctrl+Q**: Quit application - Exits the application (with confirmation dialog)
+- **Ctrl+E**: Export data - Opens the export dialog window
+
+## Data Management
+- **Ctrl+N**: Clear entries - Clears all input fields to start a new entry
+- **Ctrl+R** or **F5**: Refresh data - Reloads data from the CSV file and updates the display
+
+## Window Management
+- **Ctrl+M**: Manage medicines - Opens the medicine management window
+- **Ctrl+P**: Manage pathologies - Opens the pathology management window
+
+## Table Operations
+- **Delete**: Delete selected entry - Deletes the currently selected entry in the table (with confirmation)
+- **Escape**: Clear selection - Clears the current selection in the table
+- **Double-click**: Edit entry - Opens the edit dialog for the selected entry
+
+## Help
+- **F1**: Show keyboard shortcuts help - Displays a dialog with all available keyboard shortcuts
+
+## Implementation Details
+
+### Menu Integration
+All keyboard shortcuts are displayed in the menu bar next to their corresponding menu items for easy reference.
+
+### Button Labels
+Primary action buttons show their keyboard shortcuts in the button text (e.g., "Add Entry (Ctrl+S)").
+
+### Case Sensitivity
+- Shortcuts are case-insensitive
+- Both `Ctrl+S` and `Ctrl+Shift+S` work
+- Uppercase and lowercase variants are supported
+
+### Focus Requirements
+- Keyboard shortcuts work when the main window has focus
+- Focus is automatically set to the main window on startup
+- Shortcuts work across all tabs and interface elements
+
+### Feedback System
+- All operations provide feedback through the status bar
+- Success and error messages are displayed
+- Confirmation dialogs are shown for destructive operations (quit, delete)
+
+## Usage Tips
+
+### Quick Workflow
+1. **Ctrl+N** - Clear fields for new entry
+2. Enter data in the form
+3. **Ctrl+S** - Save the entry
+4. **F5** - Refresh to see updated data
+
+### Navigation
+- Use **Ctrl+M** and **Ctrl+P** to quickly access management windows
+- Use **Delete** to remove unwanted entries from the table
+- Use **Escape** to clear selections when needed
+
+### Getting Help
+- Press **F1** anytime to see the keyboard shortcuts help dialog
+- All shortcuts are also visible in the menu bar
+- Button tooltips show additional keyboard shortcut information
+
+## Accessibility
+- Keyboard shortcuts provide full application functionality without mouse use
+- All critical operations have keyboard equivalents
+- Shortcuts follow standard application conventions (Ctrl+S for save, Ctrl+Q for quit)
+- Help system is easily accessible via F1
diff --git a/docs/README.md b/docs/README.md
index fc4cbd8..b610e29 100644
--- a/docs/README.md
+++ b/docs/README.md
@@ -11,6 +11,11 @@ Welcome to TheChart documentation! This guide will help you navigate the availab
   - Advanced Dose Tracking
   - Graph Visualizations
   - Data Management
+  - Keyboard Shortcuts
+- **[Keyboard Shortcuts](KEYBOARD_SHORTCUTS.md)** - Comprehensive shortcut reference
+  - File operations shortcuts
+  - Data management shortcuts
+  - Navigation shortcuts
 
 ### For Developers
 - **[Development Guide](DEVELOPMENT.md)** - Development setup and testing
diff --git a/scripts/test_keyboard_shortcuts.py b/scripts/test_keyboard_shortcuts.py
new file mode 100644
index 0000000..ca0c231
--- /dev/null
+++ b/scripts/test_keyboard_shortcuts.py
@@ -0,0 +1,93 @@
+#!/usr/bin/env python3
+"""
+Test script for keyboard shortcuts functionality.
+This script tests that the keyboard shortcuts are properly bound.
+"""
+
+import os
+import sys
+import tkinter as tk
+
+# Add the src directory to the path so we can import the main module
+sys.path.insert(0, os.path.join(os.path.dirname(__file__), "..", "src"))
+
+from main import MedTrackerApp
+
+
+def test_keyboard_shortcuts():
+    """Test that keyboard shortcuts are properly bound."""
+    print("Testing keyboard shortcuts...")
+
+    # Create a test window
+    root = tk.Tk()
+    root.withdraw()  # Hide the window for testing
+
+    try:
+        # Create the app instance
+        app = MedTrackerApp(root)
+
+        # Test that the shortcuts are bound
+        expected_shortcuts = [
+            "<Control-s>",
+            "<Control-S>",
+            "<Control-q>",
+            "<Control-Q>",
+            "<Control-e>",
+            "<Control-E>",
+            "<Control-n>",
+            "<Control-N>",
+            "<Control-r>",
+            "<Control-R>",
+            "<F5>",
+            "<Control-m>",
+            "<Control-M>",
+            "<Control-p>",
+            "<Control-P>",
+            "<Delete>",
+            "<Escape>",
+            "<F1>",
+        ]
+
+        # Check if shortcuts are bound
+        bound_shortcuts = []
+        for shortcut in expected_shortcuts:
+            if root.bind(shortcut):
+                bound_shortcuts.append(shortcut)
+
+        print(f"Successfully bound {len(bound_shortcuts)} keyboard shortcuts:")
+        for shortcut in bound_shortcuts:
+            print(f"  ✓ {shortcut}")
+
+        # Test that methods exist
+        methods_to_test = [
+            "add_new_entry",
+            "handle_window_closing",
+            "_open_export_window",
+            "_clear_entries",
+            "refresh_data_display",
+            "_open_medicine_manager",
+            "_open_pathology_manager",
+            "_delete_selected_entry",
+            "_clear_selection",
+            "_show_keyboard_shortcuts",
+        ]
+
+        for method_name in methods_to_test:
+            if hasattr(app, method_name):
+                print(f"  ✓ Method {method_name} exists")
+            else:
+                print(f"  ✗ Method {method_name} missing")
+
+        print("\n✅ Keyboard shortcuts test completed successfully!")
+        return True
+
+    except Exception as e:
+        print(f"❌ Error during testing: {e}")
+        return False
+    finally:
+        root.destroy()
+
+
+if __name__ == "__main__":
+    success = test_keyboard_shortcuts()
+    sys.exit(0 if success else 1)
diff --git a/src/main.py b/src/main.py
index b44a509..8c9d72a 100644
--- a/src/main.py
+++ b/src/main.py
@@ -72,6 +72,9 @@ class MedTrackerApp:
         # Add menu bar
         self._setup_menu()
 
+        # Setup keyboard shortcuts
+        self._setup_keyboard_shortcuts()
+
         # Center the window on screen
         self._center_window()
 
@@ -141,12 +144,12 @@ class MedTrackerApp:
             self.input_frame,
             [
                 {
-                    "text": "Add Entry",
+                    "text": "Add Entry (Ctrl+S)",
                     "command": self.add_new_entry,
                     "fill": "both",
                     "expand": True,
                 },
-                {"text": "Quit", "command": self.handle_window_closing},
+                {"text": "Quit (Ctrl+Q)", "command": self.handle_window_closing},
             ],
         )
 
@@ -172,19 +175,126 @@ class MedTrackerApp:
         # File menu
         file_menu = tk.Menu(menubar, tearoff=0)
         menubar.add_cascade(label="File", menu=file_menu)
-        file_menu.add_command(label="Export Data...", command=self._open_export_window)
+        file_menu.add_command(
+            label="Export Data...",
+            command=self._open_export_window,
+            accelerator="Ctrl+E",
+        )
         file_menu.add_separator()
-        file_menu.add_command(label="Exit", command=self.handle_window_closing)
+        file_menu.add_command(
+            label="Exit", command=self.handle_window_closing, accelerator="Ctrl+Q"
+        )
 
         # Tools menu
         tools_menu = tk.Menu(menubar, tearoff=0)
         menubar.add_cascade(label="Tools", menu=tools_menu)
         tools_menu.add_command(
-            label="Manage Pathologies...", command=self._open_pathology_manager
+            label="Manage Pathologies...",
+            command=self._open_pathology_manager,
+            accelerator="Ctrl+P",
         )
         tools_menu.add_command(
-            label="Manage Medicines...", command=self._open_medicine_manager
+            label="Manage Medicines...",
+            command=self._open_medicine_manager,
+            accelerator="Ctrl+M",
         )
+        tools_menu.add_separator()
+        tools_menu.add_command(
+            label="Clear Entries", command=self._clear_entries, accelerator="Ctrl+N"
+        )
+        tools_menu.add_command(
+            label="Refresh Data", command=self.refresh_data_display, accelerator="F5"
+        )
+
+        # Help menu
+        help_menu = tk.Menu(menubar, tearoff=0)
+        menubar.add_cascade(label="Help", menu=help_menu)
+        help_menu.add_command(
+            label="Keyboard Shortcuts",
+            command=self._show_keyboard_shortcuts,
+            accelerator="F1",
+        )
+        help_menu.add_command(label="About", command=self._show_about_dialog)
+
+    def _setup_keyboard_shortcuts(self) -> None:
+        """Set up keyboard shortcuts for common actions."""
+        # Bind keyboard shortcuts to the main window
+        self.root.bind("<Control-s>", lambda e: self.add_new_entry())
+        self.root.bind("<Control-S>", lambda e: self.add_new_entry())
+        self.root.bind("<Control-q>", lambda e: self.handle_window_closing())
+        self.root.bind("<Control-Q>", lambda e: self.handle_window_closing())
+        self.root.bind("<Control-e>", lambda e: self._open_export_window())
+        self.root.bind("<Control-E>", lambda e: self._open_export_window())
+        self.root.bind("<Control-n>", lambda e: self._clear_entries())
+        self.root.bind("<Control-N>", lambda e: self._clear_entries())
+        self.root.bind("<Control-r>", lambda e: self.refresh_data_display())
+        self.root.bind("<Control-R>", lambda e: self.refresh_data_display())
+        self.root.bind("<F5>", lambda e: self.refresh_data_display())
+        self.root.bind("<Control-m>", lambda e: self._open_medicine_manager())
+        self.root.bind("<Control-M>", lambda e: self._open_medicine_manager())
+        self.root.bind("<Control-p>", lambda e: self._open_pathology_manager())
+        self.root.bind("<Control-P>", lambda e: self._open_pathology_manager())
+        self.root.bind("<Delete>", lambda e: self._delete_selected_entry())
+        self.root.bind("<Escape>", lambda e: self._clear_selection())
+        self.root.bind("<F1>", lambda e: self._show_keyboard_shortcuts())
+
+        # Make the window focusable so it can receive key events
+        self.root.focus_set()
+
+        logger.info("Keyboard shortcuts configured:")
+        logger.info("  Ctrl+S: Save/Add new entry")
+        logger.info("  Ctrl+Q: Quit application")
+        logger.info("  Ctrl+E: Export data")
+        logger.info("  Ctrl+N: Clear entries")
+        logger.info("  Ctrl+R/F5: Refresh data")
+        logger.info("  Ctrl+M: Manage medicines")
+        logger.info("  Ctrl+P: Manage pathologies")
+        logger.info("  Delete: Delete selected entry")
+        logger.info("  Escape: Clear selection")
+        logger.info("  F1: Show keyboard shortcuts help")
+
+    def _show_keyboard_shortcuts(self) -> None:
+        """Show a dialog with keyboard shortcuts information."""
+        shortcuts_text = """Keyboard Shortcuts:
+
+File Operations:
+• Ctrl+S: Save/Add new entry
+• Ctrl+Q: Quit application
+• Ctrl+E: Export data
+
+Data Management:
+• Ctrl+N: Clear entries
+• Ctrl+R / F5: Refresh data
+
+Window Management:
+• Ctrl+M: Manage medicines
+• Ctrl+P: Manage pathologies
+
+Table Operations:
+• Delete: Delete selected entry
+• Escape: Clear selection
+• Double-click: Edit entry
+
+Help:
+• F1: Show this help dialog"""
+
+        messagebox.showinfo("Keyboard Shortcuts", shortcuts_text, parent=self.root)
+
+    def _show_about_dialog(self) -> None:
+        """Show about dialog."""
+        about_text = """TheChart - Medication Tracker
+
+A simple application for tracking medications and pathologies.
+
+Features:
+• Add daily medication and pathology entries
+• Visual graphs and charts
+• Data export capabilities
+• Keyboard shortcuts for efficiency
+
+Use Ctrl+S to save entries and Ctrl+Q to quit."""
+
+        messagebox.showinfo("About TheChart", about_text, parent=self.root)
 
     def _open_export_window(self) -> None:
         """Open the export window."""
@@ -231,12 +341,12 @@ class MedTrackerApp:
             self.input_frame,
             [
                 {
-                    "text": "Add Entry",
+                    "text": "Add Entry (Ctrl+S)",
                     "command": self.add_new_entry,
                     "fill": "both",
                     "expand": True,
                 },
-                {"text": "Quit", "command": self.handle_window_closing},
+                {"text": "Quit (Ctrl+Q)", "command": self.handle_window_closing},
             ],
         )
 
@@ -254,6 +364,43 @@ class MedTrackerApp:
         # Update status to show completion
         self.ui_manager.update_status("UI refreshed successfully", "success")
 
+    def _delete_selected_entry(self) -> None:
+        """Delete the currently selected entry in the table."""
+        selection = self.tree.selection()
+        if not selection:
+            self.ui_manager.update_status("No entry selected for deletion", "warning")
+            return
+
+        item_id = selection[0]
+        item_values = self.tree.item(item_id, "values")
+
+        if messagebox.askyesno(
+            "Delete Entry",
+            f"Are you sure you want to delete the entry for {item_values[0]}?",
+            parent=self.root,
+        ):
+            date: str = item_values[0]
+            logger.debug(f"Deleting entry with date={date}")
+
+            self.ui_manager.update_status("Deleting entry...", "info")
+            if self.data_manager.delete_entry(date):
+                self.ui_manager.update_status("Entry deleted successfully!", "success")
+                messagebox.showinfo(
+                    "Success", "Entry deleted successfully!", parent=self.root
+                )
+                self.refresh_data_display()
+            else:
+                self.ui_manager.update_status("Failed to delete entry", "error")
+                messagebox.showerror(
+                    "Error", "Failed to delete entry", parent=self.root
+                )
+
+    def _clear_selection(self) -> None:
+        """Clear the current selection in the table."""
+        if self.tree.selection():
+            self.tree.selection_remove(self.tree.selection())
+            self.ui_manager.update_status("Selection cleared", "info")
+
     def handle_double_click(self, event: tk.Event) -> None:
         """Handle double-click event to edit an entry."""
         logger.debug("Double-click event triggered on treeview.")